Myogenin suppresses apoptosis induced by angiotensin II in human induced pluripotent stem cell-derived cardiomyocytes

Angiotensin II (Ang II), an important component of the renin–angiotensin system (RAS), plays a critical role in pathogenesis cardiovascular disorders. In addition, human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have been considered as promising platform for studying personalized medicine heart diseases. However, whether Ang can induce apoptosis hiPSC-CMs is not known. this study, we treated with different concentrations [0 nM (vehicle control), 1 nM, 10 100 ?M, and mM] various time periods (24 h, 48 6 days, days) analyzed viability hiPSC-CMs. We found that treatment mM days reduced by 41% (p = 2.073E-08) increased 2.74-fold, compared to control group 6.248E-12). MYOG, which encodes muscle-specific transcription factor myogenin, was also identified apoptosis-suppressor gene II-treated Ectopic MYOG expression decreased Further analysis RNA sequencing (RNA-seq) data illustrated myogenin ameliorated II-induced downregulating proinflammatory genes. Our findings suggest induces attenuates apoptosis.